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Cofactor D&A™ is your
Design & Analysis research
department. The best possible results begin with the best possible people.
Read more about Cofactor
About Cofactor
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Cofactor D&A™ is your
Design & Analysis research
department. The best possible results begin with the best possible people.
Read more about Cofactor
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Introduction
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Discover what more and more researchers are finding out every day... Cofactor Genomics is not a resource just for sequencing. We offer the bookends that make the sequencing data really matter. That's our D&ATM Design & Analysis solution.
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Who is Cofactor
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Cofactor Genomics is a privately held biotechnology company that employs experimental design, next-‐generation sequencing, and proprietary analysis technology and pipelines to drive the discovery and design of new products and processes for the life sciences field. Cofactor’s D&A (Design & Analysis) Solution is constructed to specifically assist those researchers who require more than just sequencing at a reasonable cost. It also provides expert design and analysis capabilities, customized to specific requirements, and bioinformatics to make the most of the data that is generated. Cofactor’s expertise in molecular biology and bioinformatics accelerates its partners’ biological research, discovery and product development in a number of scientific areas worldwide.
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Sequencing Platforms
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Cofactor Genomics currently offers the following sequencing platforms.
- Illumina
- GAIIx
- HiSeq 2000
- Life Technologies
- Ion Torrent PGM
- SOLiD 4
- Roche 454
- FLX
- Junior
Each platform has strengths and weaknesses that make it more or less appropriate for your application. At Cofactor, platform choice and optimization is for us to worry about. All you have to do is describe your research question to us. We'll design your project to choose an optimal platform (or combination of platforms) that minimizes your total fiscal impact without sacrificing the quality of the data or results.
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Illumina GAIIx
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- Broad range of high-throughput sequencing applications,including whole genome
DNA sequencing, gene expression, small RNA discovery, and protein-nucleic
- acid interactions
- Powerful combination of 2x100 base pair read lengths and up to 480 million paired end reads per flow cell
- De novo sequence assembly (whole genome and transcriptome)
- Whole genome or targeted resequencing RNA sequencing, small RNA sequencing, RIP-seq Single-read, paired-end and multiplexing capability
- Most widely used platform with more than 90 Science or Nature publications
- With paired-end platform module, templates can be read in both directions for more than 48 Gb of data per run
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Life Technologies Ion Torrent PGM
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- Massively scalable semiconductor technology currently capable of 100 MB, and
soon to be 1Gb, of high quality data output - Simple chemistry: utilizes real-time pH measurement duringDNA replication, directly converting pHreadsinto base calls, meaning faster turnaround with increasing data reliability
- Supports fast turnaround with only a 4 hour turn around time per run
- Leverages over one trillion dollars in industry semiconductor research
- Low cost makes diagnostic and amplicon sequencing significantly more affordable
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Life Technologies SOLiD 4
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- Up to 99.99% accuracy; causative variation detections at lower coverage and cost per sample
Up to 50 Gb of mappable sequence data per run- True paired-end sequencing: detection of genetic alterations,splice variants and fusion transcripts facilitated by AB’s bidirectional sequencing capability
- Intelligent bar coding increases accuracy of assignments and decreases bias
- Higher quality sequence data at a lower per run cost
- Highly accurate single nucleotide polymorphism (SNP) detection aided by unique AB 2-base encoding technology
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Roche 454 FLX Junior
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- Average read length of 400 base pairs
- 99% accurate at 400 base pair read length
- 100,000 shotgun reads / run, 70,000 amplicon reads / run
- gDNA, amplicons, cDNA, BAC sample input compatible
- Linux-based operating system on an HP computer
- Extremely fast turnaround, with 100 Mb output in only four hours
- Straightforward tools that help de novo assembly, mapping, and amplicon variant analysis
- De novo sequencing at an affordable price
- Targeted resequencing (high sensitivity amplicon-seq)
- Metagenomic characterization to map species diversity
- Longer read lengths aid greatly in producing longer contigs as a standalone platform or combined with others
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Next-Gen Sequencing… and Beyond
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Competing in today's scientific environment, both commercial and academic, necessitates the use of the latest technology. Cofactor allows researchers to move beyond studying markers and genes to full genome, transcriptome and epigenome characterization. Next-Gen makes possible previously impractical experiments such as environmental, population, and metagenomics.
While this technology offers new promise to life science and medical researchers, it also creates complex challenges. The experts at Cofactor have significant experience analyzing terabytes of data and exploiting the unique strengths of each Next-Gen platform. We call it our D&A™ Solution. You will call it the best possible pathway to getting meaningful results for your experiment.
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Why Cofactor D&A?
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Cofactor is truly unique in what we bring to sequencing. That is because we take a holistic approach to your experiment, beginning with the proper design and finishing with analysis that lets you get meaningful results to take your research to the next level.
Oftentimes, science can leave us with more questions than answers. Cofactor’s goal is to provide those answers with our expertise in design and analysis. Our D&A™ Solution is designed specifically to assist those researchers who require more than just sequencing at a reasonable cost. We offer expert design and analysis capabilities that are customized to your specific requirements, helping make sense of the quality data that we generate.
Cofactor D&A™ is what enables us to provide the best possible results for your experiment. For all the questions your experiments generate, Cofactor can help provide the answers:
- How do I get the best results from my experiment?
- Is my sample too small?
- How do I know which genes to focus on?
- Where can I go for my De Novo sequencing?
- Who can provide the bioinformatics I need?
- I know sequencing, but what about the analysis?
- Who has experience sequencing this organism?
- How do read lengths fit in?
- Who can sequence plant, animal, and human DNA and RNA?
- Which provider has perfected the library generation process?
- Which Next-Gen sequencing platform is right for my project?